| abstract |
An oxazolidine derivative represented by general formula (I), a salt thereof, a process for the production thereof, an antihyperlipidemic containing the same as the active ingredient, and a method of curing hyperlipidemia by administering the came, wherein R1, R~ and R3 represent each H, optionally halogenated alkyl, optionally halogenated alkoxy, OH, halo, NO2, optionally acetylated or alkylated amino, COOH, alkoxycarbonyl, CN, alkanoyl or 2-oxazolyl, provided that R1 and R~ may be combined with each other to represent -(CH2)p- or -O-(CH2)q-O-, wherein p represents 3 to 5 and q represents 1 to 3, thus forming a cyclic structure; m and n represent each 0 or 1; R4 and R5 represent each H or alkyl; X represents C or N; Y represents CH2OH, CHO or COOR6, R6 representing alkyl, benzyl or H; A represents alkylene, carbonyl or sulfonyl; B represents alkylene; E represents optionally halogenated alkylene or alkenylene; and Z represents O or S; provided that the case where n is O, m is 1 and Y is CH2OH and the case where n is O and Y is COOR6, R6 being alkyl, are excluded. (see fig. I) (I) |