| abstract |
The present invention discloses compounds of the formula (see formula I) or a pharmaceutically-acceptable addition salt thereof wherein R' and R" independently of each other are hydrogen or alkyl, or R' and R" together form a 3 to 6 membered alkylene chain; one of R1 and R2 is aryl which may be substituted one or more times with halogen, CF3; CN, OH, alkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, amino, nitro, sulphamoyl, tetrazolyl, CO2H, CO2-alkyl and the other of R1 and R2 is hydrogen, halogen, alkoxy, amino or alkyl; and R4; R5, R6 and R7 independently of each other are hydrogen; halogen, amino, nitro, CN; OH; CF3, alkyl or alkoxy; and n is 0 or 1; provided that neither of R1 and R2 is phenyl or substituted phenyl when n is 0. The compounds are useful as pharmaceuticals, for example, in the treatment of ischemia, anoxia, migraine and psychosis. |