| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_55f8b4a24fa698ac5171923c274ca5ac |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2896
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-30 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-865
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08 |
| filingDate |
1992-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed72b74b15084d615f1df24dfedf72e2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e14b336d3586639e9b2747458546b36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c3875c8c00f094972c79e06d935bed7 |
| publicationDate |
1992-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-2110799-A1 |
| titleOfInvention |
Microbially-produced antibody fragments and their conjugates |
| abstract |
Recombinant DNA methods are described for the production of antibody F(ab')2 and Fab' fragment molecules from transformed microorganisms such as bacteria and yeast. The recombinant F(ab')2 and Fab' fragments are secreted from the host cells and may be recovered directly from the fermentation culture. These direct methods of F(ab')2 and Fab' production are advantageous over existing art methods by avoiding proteolytic digestions and obtaining homogeneous molecules. Methods are described for the conjugation of these fragments, by methods targeting either available lysine amino acid residues or selectively-reducible cysteine residues, to active moieties such as ricin toxin A chain. The microbially-produced F(ab')2 and Fab' fragment molecules and their immunoconjugates have a wide variety of therapeutic and diagnostic uses. |
| priorityDate |
1991-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |