| abstract |
Abstract Diaminobenzoic acid derivatives The invention relates to compounds of the formula I (I) in which A1 and A2 are hydrogen, unsubstituted or substituted lower alkyl, lower alkenyl or lower alkynyl, heterocyclyl-lower-alkyl, acyl, lower alkylsulfonyl or arylsulfonyl, or together are unsubstituted or substituted lower alkylene; Ar1 and Ar2 are aryl, heteroaryl or unsubstituted or substituted cycloalkyl, X is O or S, Y is amino, substituted amino, substituted lower alkoxy or unsubstituted or substituted lower alkylthio; or, if X is O and Z is substituted methyl, Y is hydroxyl; and Z is substituted methyl, carboxyl or esterified or amidated carboxyl or thiocarboxyl; or Y and Z together are 1-oxamethylene; to salts thereof, tautomers thereof, processes for their preparation, pharmaceutical compositions, and/or to these compounds for the therapeutic treatment of the human or animal body or for the preparation of pharmaceutical compositions. The compounds inhibit protein kinases. |