http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2107334-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c2b9dc89cc4ba060cc73bbf0c90bbb78 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C327-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C327-32 |
| filingDate | 1992-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87c05d055e3fa5259d2ade9f9c545749 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_541bc0b025538d459ad09a125a479912 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5bb5baf770fa44ada926fcfd06a6aefc |
| publicationDate | 1992-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2107334-A1 |
| titleOfInvention | Thiol-carboxylic acid derivatives as collagenase inhibitors |
| abstract | A compound of formula (I) or a salt, solvate or hydrate thereof in which, R1 is -OH; alkoxy; aryloxy or aralkyloxy; -NR6R7, where each of R6 and R7 is independently hydrogen or alkyl, or R6 and R7 together with the nitrogen atom to which they are bonded form a 5-, 6- or 7-membered ring with an additional oxygen, sulphur or optionally substituted nitrogen atom in the ring; or a group (II) where R8 is hydrogen; alkyl optionally substituted by -OH, alkoxy, -NR6R7, guanidine, -CO2H, CONH2, SH, or S-alkyl; or -CH2-Ar where Ar is optionally substituted aryl; and R9 is alkoxy; OH; or -NR6R7; R2 is hydrogen; or acyl, such as (a) or (b)-, where Z is optionally substituted aryl; R3 is C3-6 alkyl; R4 is -(CH2)nNR10R11, -(CH2)nNHCOR12, -(CH2)nNR13C(=NR14)NR10R11, -(CH2)nCONH(CH2)qNR10R11 or -(CH2)n-R15 where n is an integer from 1 to 6, and q is an integer from 2 to 4, and each of R10 and R11 is independently hydrogen or alkyl, or R10 and R11 together with the nitrogen atom to which they are bonded form a 5-, 6- or 7-membered ring with an optional oxygen or sulphur atom or an optionally substituted second nitrogen atom in the ring, R12 is alkyl, alkoxy, aralkyloxy or -(CH2)mNR10R11, where m is 1 or 2, R13 is hydrogen or alkyl, R14 is hydrogen or alkyl or R14 and R10 together with the nitrogen atoms to which they are bonded form an optionally substituted 5-, 6- or 7-membered ring, and R15 is an optionally substituted piperidyl ring; and R5 is hydrogen, alkyl, -CH2-(CH2)nOR16, -CH2-(CH2)n-OCOR17 or (III) where n is an integer from 1 to 6, R16, R17 and R18 are independently hydrogen or C1-6 alkyl, and R19 is hydroxy, -O-C1-6alkyl or NR10R11 where R10 and R11 are as defined for R4, for use in the treatment of collagenolytic conditions. |
| priorityDate | 1991-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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