| abstract |
NOVEL 2-SACCHARINYLMETHYL PHOSPHATES, PHOSPHONATES AND PHOSPHINATES USEFUL AS PROTEOLYTIC ENZYME: INHIBITORS AND COMPOSITIONS AND METHOD OF USE THEREOF ABSTRACT 4-R1-R2-R3-2-Saccharinylmethyl phosphates, phosphonates and phosphinates of formula I herein, useful in the treatment of degenerative diseases, and compositions containing them, methods for using them to treat degenerative diseases, and processes for their preparation by reaction of the corresponding 2-halomethylsaccharins with aphosphate, phosphonate or phosphinic acid of formula III herein in the presence of an acid-acceptor. |