| abstract |
ABSTRACT The invention refers to new iodinated, non-ionic X-ray contrasting agents with a dimeric structure with the general formula I, in which the bridging link is glycine or an N-substituted glycine I where R1 is a linear or branched polyhydroxyalkyl of 2 to 4 carbon atoms, R2 is a hydrogen, methyl or linear polyhydroxyalkyl residue of 2 to 3 carbon atoms, R3 and R8, which may be the same or different are hydrogen, methyl or 2-hydroxyethyl, R4 is a linear or branched polyhydroxylalkyl of 2 to 4 carbon atoms, R5 is methyl, hydroxymethyl or methoxymethyl, and R6 and R7 which may be the same or different are hydrogen, methyl, hydroxyethyl or 2,3-dihydroxypropyl, R2 and R5 together being able to form a group of the type where n may be from 0 to 3. The invention also refers to procedures for the obtention of products of formula I, and preparations which are pharmaceutically acceptable that contain these products. |