| abstract |
Compounds of formula (I): (see formula I) [in which: R1 is hydrogen, alkyl, cycloalkyl or alkanoyl; R2 is a single bond, alkylene or alkylidene; R3 and R4 are each hydrogen or alkyl; R6 is carboxy or tetrazol-5-yl; and X is oxygen or sulfur]; and pharmaceutically acceptable salts and esters thereof are AII antagonists and can be used for the treatment and prophylaxis of hypertension and cardiovascular diseases. |