http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2095005-A1

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filingDate 1993-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_144298c8982087bdb7ec4434bb24b8ca
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4c48884f652f735312427f9a62e1e320
publicationDate 1993-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-2095005-A1
titleOfInvention Hydroxylamine derivatives
abstract A B S T R A C T HYDROXYLAMINE DERIVATIVES The invention concerns hydroxylamine derivatives of the formula I I wherein R4 is hydrogen, carbamoyl, (1-4C)alkyl, cyclopentyl, cyclohexyl, tetrahydrofuran-3-yl, tetrahydropyran-4-yl, piperidin-4-yl, N-(1-4C)alkylpiperidin-4-yl, (2-5C)alkanoyl, (1-4C)alkylsulphonyl, N-(1-4C)alkylcarbamoyl, N,N-di-(1-4C)-alkylcarbamoyl, phenyl, phenyl-(1-4C)alkyl, di-phenyl-(1-4C)alkyl, benzoyl, phenylsulphonyl or a heteroarylmethyl group; R5 is hydrogen, (1-4C)alkyl, (3-4C)alkenyl, (3-4C)alkynyl, cyano-(1-4C)alkyl, phenyl or phenyl-(1-4C)alkyl; A4 is (1-4C)alkylene; Ar1 is phenylene, pyridinediyl or pyrimidinediyl; A1 is a direct link to X1, or A1 is (1-4C)alkylene; x1 is oxy, thio, sulphinyl or sulphonyl; Ar2 is phenylene, pyridinediyl, pyrimidinediyl, thiophenediyl, furandiyl or thiazolediyl; R1 is hydrogen, (1-4C)alkyl, (3-4C)alkenyl or (3-4C)alkynyl; and R2 and R3 together form a group of the formula -A2-X2-A3-wherein each of A2 and A3 is independently (1-3C)alkylene and X2 is oxy, thio, sulphinyl, sulphonyl or imino; or a pharmaceutically-acceptable salt thereof; processes for their manufacture; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors.
priorityDate 1992-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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