| abstract |
Disclosed are 1) the cDNA and amino acid sequences for novel polypeptide chains useful as subunits of dimeric osteogen-ic proteins, 2) osteogenic devices comprising these proteins in association with an appropriate carrier matrix, 3) methods of prod-ucing the polypeptide chains using recombinant DNA technology, and 4) methods of using the osteogenic devices to mimic the natural course of endochondral bone formation in mammals. |