http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2087104-C
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_571b8abacacea64d3f7089d0983b8b3b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B57-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-472 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4725 |
| filingDate | 1991-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1998-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_253d477f0216b2d1e983423d0c8077d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_afd420594707a96550e793299d6679e9 |
| publicationDate | 1998-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2087104-C |
| titleOfInvention | Neuromuscular blocking agents |
| abstract | 1R-cis, 1'R-cis isomer of 2',2'-(3,11-dioxo-4,10-dioxatridecylene)-bis-(1,2,3,4-tetrahydro-6,7-di-methoxy-2-methyl-1-vera-trylisoquinolinium) salt of formula (I) (see fig. I) wherein X~ is a physiologically acceptable anion substantially free from other geometrical and optical isomers thereof. The 1R-cis,1'R-cis isomer has been found to have an advantageous combination of pharmacologically properties, notably greater neuromuscular blocking potency, weaker histamine-releasing potency, and at equivalent levels of neuromuscular blockage, fewer potential adverse effects on the autonomic nervous system (sympathetic and parasympathetic blockade), in comparison with the known mixture of geometrical and optical isomers. |
| priorityDate | 1990-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 79.