http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2084074-A1
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d7dfd84f9157ae12c41e319ec325338d |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-53 |
classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-53 |
filingDate | 1991-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d6a6647ee885d0f48590d2ce2631ec50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74b7ec523a1ea4c65d6cbc95620253e9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5628d8fee831109fc0ac977d33b3acca http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4f59e396ae10fe9e23b677d90daf74a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4bf1e72b2b86cbb67d5cd26a219fd891 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4d8ba472e703856b58ecb33b66af0be |
publicationDate | 1991-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CA-2084074-A1 |
titleOfInvention | Megakaryocyte colony stimulating factor and production thereof |
abstract | (57) Abstract A homogeneous megakaryocyte colony stimulating factor (Meg-CSF) comprising a protein having an activity of forming a megakaryocyte colony from human or mouse myelloid cells in vitro and an activity of increasing the numbers Or megakaryocyte precursor cells and megakaryocytes in vivo, said Meg-CSF being produced by culturing cell strains of a large human-derived pul-monary cell carcinoma, e.g. PC-13 strains, or human pulmonary carcinoma cell strains, i.e. MC-1 strains, separated as monoclon-al cells from the PC-13 strains, recovering the supernatant of the resulting culture medium, separating the Meg-CSF from the su-pernatant, and purifying it by a newly developed purification technique. The obtained homogeneous Meg-CSF is a homogeneous protein having a molecular weight of about 23,000 according to gel filtration or about 20,000 according to SDS-PAGE and an isoelectric point of 4.5 to 5.5. The partial amino acid sequence of the protein has been determined. The homogeneous Meg-CSF is useful for treating a certain kind of thrombocytopenia. |
priorityDate | 1990-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 725.