http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2079992-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_afd115dec46c157d3739020ebd4d866b |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/H03H9-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 |
| filingDate | 1992-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1471d337c8304b3879b7cf24a33d78ce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a888190da8fef6e758d47883906240cf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b7014e94fd190bff71bec0a57506816 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1bdd07c0fbec1b604d833df41bc32b20 |
| publicationDate | 1993-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2079992-A1 |
| titleOfInvention | Mutant human prourokinase |
| abstract | ABSTRACT OF THE DISCLOSURE A mutant human prourokinase wherein a neutral amino acid in the epidermal growth factor (EGF) region of human prourokinase (human PUK) has been replaced with a basic amino acid, or an acidic amino acid has been replaced with a non-acidic amino acid, and a method for producing a mutant human PUK which comprises expression of mutant human PUK by cultivating a host transformed by a plasmid inserted with a DNA sequence coding for said mutant human PUK. By replacing a neutral amino acid in the EGF region of human PUK which is a fibrinolysin with a basic amino acid, or an acidic amino acid with a non-acidic amino acid, half-life in blood can be prolonged, and affinity for fibrin can be improved. |
| priorityDate | 1991-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 628.