| abstract |
TITLE OF THE INVENTION SUBSTITUTED DERIVATIVES OF PIPERIZINYLCAMPHORSULFONYL OXYTOCIN ANTAGONISTS ABSTRACT OF THE INVENTION Compounds of the formula: - i - 18449 wherein R is oxime, hydroxy, halolgen, cyclic epoxide, alkylcarbonyloxy, alkoxycarbonylalkoxy, trihalo-alkylsulfonyloxo, or unsubstituted or substituted oxo, where said substituent is unsubstituted or substituted saturated 6-membered heterocyclic rings having 1 or 2 heteroatoms which are N, and said substituent is alkyl. The compounds of formula I are oxytocin antagonists useful in the treatment of preterm labor, dysmenorrhea and for the stoppage of labor preparatory to cesarean delivery. Also disclosed are pharmaceu-tical compositions containing these compounds, methods of their use and methods of their preparation. |