| abstract |
Compounds of the formula wherein X is -O- or CH2-; Y is -O-,-CH2-CH2-,-CH=CH-,-C?C- or -OCH2C6H4-; Z is -CH2-CH2-,-CH=CH-or-C?C-; R1 is hydrogen, lower alkyl, lower alkenyl cycloalkyl or aralky; A is-B or -O-B; B is a mono, di- or tricyclic aromatic or heteroaromatic moiety substituted by the group -COR2, -(O)t-(W)s-COR2or-(CH=CH)pCOR2 and which may also contain up to 4 additional substituents selected, independently, from the group consisting of halogen,cyano,loweralkyl,lower alkoxy, sulfonamido, alkanoyl, aroyl, -(Q)k-(W)5-E or -(Q)k- (W)S-C6H4-(W)S"'-E, provided that no more than one of said substituents is -(Q)k-(W)S'-Eor-(Q)k-(W)S"'-C6H4-(W)S"'-C6H4-(W)5"'-E; E is-COR2 or R2; W is -CR3R4-; Q is -O- or carbonyl; R2 is hydroxy, lower alkoxy or -NR3R4; R3 and R4,each occurence, independently, are hydrogen or lower alkyl; f, h, k, m and t, independently, are 0 or l; n, s and s', independently, are an integer from 1 to 12; p is an integer from 1 to 2; s" and s"', independently, are an integer from 0 to 12; and C6H4 is a 1,2-, 1,3- or 1,4-phenylene moiety, their geometric and optical isomers and, when R2 hydroxy, pharmaceutically acceptable salts thereof with bases are potent leukotriene B4 antagonists and are therefore useful in the treatment of inflammatory diseases, such as psoriasis, inflammatory bowel diseases, asthma, allergy, arthritis, dermatitis, gout, pulmonaly disease, ischemia/reperfusion injury, and trauma induced inflammation, such as spinal cord injury. |