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filingDate 1991-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a5d82d28296c5b968819a5ff398e22aa
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publicationDate 1991-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-2076855-A1
titleOfInvention Method for detection of borrelia burgdorferi, purified antigen thereof and antibody capable of binding therewith
abstract The invention relates to novel antigens associated with Borrelia burgdorferi which are exported (or shed) in vivo and whose detection is a means of diagnosing Lyme disease. The antigens are extracellular membrane vesicles and other bioproducts including the major extracellular protein. The invention is further directed to antibodies, monoclonal and/or polyclonal, labeled and/or unlabeled, that react with the antigens and to a method of diagnosing Lyme disease by detecting the antigens in a biological sample taken from a host using the antibodies in conventional immunoassay formats. The invention further relates to kits, for the diagnosis of Lyme disease, comprising the antibodies and ancillary reagents. The advantage of the antibodies used in the invention is that they react with the antigens from geographically diverse strains of Borrelia burgdorferi, but do not react with antigens from related Borrelia spirochetes.
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