| abstract |
Imidazole derivatives of the formula (I): [DPIM]-S-W-Y, wherein [DPIM] represents a group of formula (DPIM), wherein R and R1 represent hydrogen, halogen or alkyl, W represents straight chain alkylene of 1 to 6 carbon atoms optionally substituted by alkyl, Y represents a group of formulas (II), (III), (IV), (V), (VI) and salts thereof, are inhibitors of acyl coenzyme-A:cholesterol-O-acyl transferase useful for the conditions such as atherosclerosis, hyperlipidaemia, cholesterol or ester storage disease and atheroma in vein grafts. |