| abstract |
Compounds of the formula: wherein R1 is carboxy or protected carboxy, R2 is hydrogen, lower alkyl or halogen, R3 is aryl or ar(lower)alkyl, each of which may have suitable substituent(s), [substituted carbamoyl](lower)alkyl, or:a group of the formula: in which is heterocyclic group containing nitrogen atom, and n is 0 or 1, R11 is hydrogen or lower alkyl, A is lower alkylene which may be substituted by oxo, or lower alkenylene, Q is carbonyl or lower alkylene, in which R4 is hydrogen or lower alkyl, and R5 is hydrogen, lower alkyl or Y-Z-R3. Y is bond or lower alkylene, Z is lower alkylene, lower alkenylene, -O-or in which R6 is hydrogen, lower alkyl, ar(lower)alkyl which may have suitable sub-stituent(s) or amino protective group, and pharmaceutically acceptables salts thereof. Pharma-ceutical compositions containing same, the preparation of these compounds and a method of treating or pre-venting testosteron 5.alpha.-reductase mediated diseases are also disclosed. The compounds according to the inven-tion are particularly useful for treating alopecia, acnes, prostatism, and the like. |