| abstract |
Thioacylating reagents are provided for the introduction of thioamide bonds into growing peptides represented by struc-ture (I), where the substituents are disclosed herein. Intermediate precursors for preparing these thioacylating reagents are also provided. A process for preparing the thioacylating reagents and the intermediate precursors is further provided. Thiopeptides, and salts thereof, that exhibit pharmacological utility are provided and are represented by formula (II), wherein R1, R3, R4, X and n are as defined herein. Methods for preparing these thiopeptides from solution and solid phase syntheses, utilizing the thioacylating reagents disclosed herein, are also provided. |