http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2059103-C
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_23e301cc66e48e50b52885ba78f02aa4 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D475-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D475-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-495 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D475-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B57-00 |
| filingDate | 1992-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1996-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ed5641486a5c5a8fb0476659f94b857 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_143e4b708522e8150269ae318557c566 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1fb7bc50f6dc312b734e915977993d8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c79f5727389328c958ab7485aa73af36 |
| publicationDate | 1996-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2059103-C |
| titleOfInvention | Process for the preparation of (6s)- and (6r)-tetrahydrofolates |
| abstract | The invention relates to a process for the preparation of (6S)- and (6R)-tetrahydrofolic acid and their addition salts with a sulfonic acid or with sulfuric acid, which is characterized in that (6R,S)-tetrahydrofolic acid is reacted with a sulfonic acid or with sulfuric acid, resulting acid addition salt is fractionally crystallized and, if desired, the (6S)- or (6R)-tetrahydrofolic acid is liberated from the resulting diastereomeric acid addition salts by treatment with a base and isolated. The invention additionally relates to the novel acid addition salts of (6S)- and (6R)-tetrahydrofolic acid with a sulfonic acid or with sulfuric acid, their use as medicaments or starting material for the prepara-tion of a medicament and their use for the preparation of optically active 5-methyl-, 5-formyl- and 5,10-methylene-tetrahydrofolic acids and their salts with strong bases and acids. |
| priorityDate | 1991-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 138.