abstract |
VILLIN GENE PROMOTER SEQUENCE AND ITS USE IN VECTORS, TRANSFORMED MAMMALIAN CELL LINES, TRANSGENIC ANIMALS, AND CELL LINES DERIVED FROM THE ANIMALS Abstract An isolated DNA sequence encoding a promoter of the human villin gene is provided. The DNA sequence can be operatively linked to a nucleotide sequence of a gene, such as an oncogene, and incorporated in cloning and expression vectors. The vectors are useful in the production of transgenic, non-human mammals as models of colorectal cancer. |