| abstract |
IN THE UNITED STATES PATENT AND TRADEMARK OFFICE PATENT APPLICATION entitled: Novel pyrimidine derivatives which are angio-tensin II receptor antagonists, their methods of preparation and pharmaceutical composi-tions in which they are present in the names of: Nicole BRU-MAGNIEZ Jean-Marie TEULON Eric NICOLAI Assignee: Laboratoires UPSA ABSTRACT OF THE DISCLOSURE The present invention relates to the deriva-tives of the formulae Formula (I) Formula (I') in which: R1 is a lower alkyl radical having 1 to 6 carbon atoms or a lower alkylene radical having 2 to 6 carbon atoms, R2 is a lower alkyl radical, an aromatic, a functional group, the hydrogen atom or a halogen atom, X can be a bond, an oxygen or sulfur atom, a radical NH or a halogen, R3 or R'3 can be a functional group, a hydrogen atom, a lower alkyl radical, an aromatic ring or a heterocycle, and R4 can be a 2-sulfobenzoylamino, 2-carboxy-3,6-dichlorobenzoylamino, 2-carboxyphenyl, 2-sulfoxyphenyl or 2-(tetrazol-5-yl)phenyl group, and their addition salts, and to their use in thera-peutics, especially for the treatment of cardiovascular diseases and in particular for the treatment of hyper-tension and cardiac insufficiency. |