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filingDate 1991-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1992-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-2042318-A1
titleOfInvention Attenuated viruses
abstract ABSTRACT ATTENUATED VIRUSES An attenuated poliovirus in which the 5' non-coding region of the genome is: (a) the 5' non-coding region of poliovirus type 3 Leon strain modified by the provision of the bases uracil and adenine at positions 472 and 537 thereof respectively, or (b) the 5' non-coding region of another poliovirus modified by the provision of the bases uracil and adenine at respective positions corresponding to position 472 and 537 of the 5' non-coding region of poliovirus type 3 Leon strain.
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