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filingDate 1991-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f2f95f7cf546c0bc194bb360b092d4b
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publicationDate 1991-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-2039306-A1
titleOfInvention Preparation of beta-ketoesters useful in preparing quinolone antibiotics
abstract A method for preparing a compound of the formula (see fig I) wherein Q is C-H or N; R1 is C1-C4 alkyl, benzyl or p-nitrobenzyl and X and Y are independently selected from fluoro and chloro comprising reacting a compound of the formula (see fig. II) wherein Q is C-H or N; X and Y are independently selected from fluoro and chloro; and Z is fluoro, chloro, 1-imidazolyl or substituted 1-imidazolyl, wherein the 1-imidazolyl group is substituted with one or two substituents independently selected from C1 to C4 alkyl, with a compound of the formula (see fig. III) wherein M is an alkaline earth metal, Cu or Mn, n is 2, VP-, wherein p is 1 or 2, is an anion of the formula (see fig. IV) or a dianion of the formula (see fig. V) and R1 is as defined above, with the proviso that when Z is 1-imidazolyl or substituted 1-imidazole, M is magnesium, copper or manganese and with the proviso that when 2 is fluoro, chloro or bromo, VP- is a dianion of the formula V(b).
priorityDate 1990-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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Total number of triples: 42.