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filingDate 1991-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c0d365055b71f86aabc1a8ed91813ba
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a04a3c0866cf632d710b179058d73f9
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publicationDate 1991-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-2037188-A1
titleOfInvention Agent for treating disorders from cerebral neuro-degeneration
abstract ABSTRACT AGENT FOR TREATING DISORDERS FROM CEREBRAL NEURO-DEGENERATION A therapeutic agent for alleviating disorders caused by nerve cell degeneration in the brain which contains a cyclopropachromen derivative represented by the following general formula (I): (I) wherein n is an integer of from 2 to 5; the carbon atom in the -(CH2)n- moiety may be option-ally substituted with a methyl group or a hydroxyl group; Rl and R2 independentlY represent a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, a phenyl group or an aralkyl group having 7 to 10 carbon atoms; or alternatively R1 and R2 form together with the nitrogen atom to which they are attached, a morpholino group, a thiomorpholino group, a pyrrolidinyl group, a piperidinyl group, a homopiperidinyl group, a piperazinyl group, a homopiperazinyl group, an N-alkylpiperazinyl group, N-alkylhomopiperazinyl group, an N-hydroxyalkylpiperazinyl group or a pyrrolidonyl group or alternatively R1 and R2 form together with the nitrogen atom to which they are attached, and further a carbon atom to which said nitrogen atom is bound, a pyrrolitidinyl group; Al and A2 independently represent a hydrogen atom, a hydroxyl group, a halogen atom, an optionally halogenated alkyl group having 1 to 5 carbon atoms, an optionally substituted alkoxy group, an acyloxy group, a carbamyloxy group or an optionally substituted carboxyl group; and Bl and B2 independently represent a hydrogen atom, a halogen atom, a nitro group, a cyano group, an optionally halogenated alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms or an optionally substituted carboxyl group; or a pharmaceutically acceptable salt thereof as an active ingredient, together with a pharmaceutical carrier or adjuvant.
priorityDate 1990-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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