| abstract |
ABSTRACT IN STIMULATING MYELOPOIESIS Heteroaryl-3-oxo-propanenitrile derivatives of formula (I) (I) wherein X represents an oxygen atom or a -CH(R4)-, -O-CH(R4)-, -S(O)n-, -S(O)n-CH(R4)-, -CH(R4)-O-, -CH(R4)-S(O)n- or -CH(R4)-CH2-group wherein n is 0, 1 or 2; R1 represents C1-C6 alkyl, pyridyl or unsubstituted or substituted phenyl; R2, R3 and R4 are as herein defined; and Q is hydrogen, carboxy, C2-C7-alkoxycarbonyl or a -CON(Ra)Rb group, Ra and Rb being as de-fined herein; and their pharmaceutically acceptable salts are useful in stimulating myelopoiesis in bone marrow suppressed mammals. |