http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2033531-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05a203d85ee01909eaf728dc16f0f6cb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
| filingDate | 1991-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_07a4e3adedb479f7ef9b4ab75a7dc046 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3e21323ecb6a0afb5da680327e7fb67 |
| publicationDate | 1991-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2033531-A1 |
| titleOfInvention | Azaoxindole derivatives |
| abstract | This invention relates to novel 4-, 5-, 6-, and 7-azaoxindole derivatives of the formula: (see fig. I) (wherein one of A, B, D and E is N and the others are CH; Y is H, OR3, OH, lower alkyl, CF3, COR3, halogen, COOR3, CONR3R3, CN, NO2, SR3, SOR3, SO2R3 or SO2NR3R3; R1 is lower alkyl or CONHR4; R2 is lower alkyl, (CH2)nR5 [where n is 0 or 1] or NHR6; R3 is H, lower alkyl, allyl, optionally substituted phenyl or optionally substituted benzyl; R4 is H, lower alkyl, hydroxyalkyl, cycloalkyl, COR3, optionally substituted phenyl or optionally substituted heteroaryl; R5 is H, cycloalkyl, optionally substituted phenyl or optionally substituted heteroaryl; R6 is phenyl, thiophene or furan, each optionally substituted; W is H, alkanoyl, cycloalkylcarbonyl, phenoxycarbonyl, acyloxyalkyl, alkoxycarbonyloxyalkyll alkylsulfonyl, lower alkyl, methylphenylsulfonyl or dialkylphosphonate, with the proviso that (a) when E is N, then at least one of X and Y is other than H; and (b) when either R2 is NHR or R1 is lower alkyl, then W is H). The compounds are anti-inflammatory and analgesic agents and inhibitors of one or more of prostaglandin H2 synthase, 5-lipoxygenase and interleukin-1 biosynthesis. They are useful in the treatment of chronic inflammatory diseases, allergy, psoriasis, various bone diseases, and immune dysfunctions such as systemic lupus erythematosis. |
| priorityDate | 1990-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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