| Predicate |
Object |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-65
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5015
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5026
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5042
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5047
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5073
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5078
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5084 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-65
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-50 |
| filingDate |
1990-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2002-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46a8874dbf675f146523f668771b25f0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_115cf94f687b8ffe3c5bdc99950385ab
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7597433ff71a31f61029ff07fb1c4ab9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5478c312e8086b75d384691ff99e75af
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3123fc98a3709496925f3e0cc236b5e1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1488d7e558a0286e9351cec4dbf6f58e |
| publicationDate |
2002-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-2025703-C |
| titleOfInvention |
Pulsatile once-a-day delivery systems for minocycline |
| abstract |
Pharmaceutical delivery systems containing 7-dimethyl-6-deoxy-6-demethyltetracycline or a non-toxic said addition salt thereof comprising mixtures or separate administration units of pH sensitive polymer coated spherical granules adapted to release the minocycline in a medium having a pH of in the range of from about 4.0 to about 7.5 and coated or uncoated quick release granules adapted to release minocycline in a medium having a pH of less than about 3.9 or minocycline powder, pH adapted multi-coated compositions and oral dosage unit forms liquids, capsules or tablets containing the above are provided. These systems and formulations provide at least minimum therapeutic blood levels of minocycline for at least about 24 hours when administered to a subject only once-a-day. Methods for the preparation of the systems and formulations are provided as well. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8268804-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9561241-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8722650-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8252776-B2 |
| priorityDate |
1989-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |