http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2025350-C
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-50 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y114-17003 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-585 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0071 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-585 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62 |
| filingDate | 1990-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2000-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ecbd20111ecefdc7319988ca819b40be http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4cfb7dcaec4b46303c5afded1d02b74a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_873432d78c8a5e4b6ed010b9eafe847e |
| publicationDate | 2000-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2025350-C |
| titleOfInvention | Process for production of c-terminal .alpha.-amidated peptide |
| abstract | Processes for the production of a peptide of the formula (III): R-X-NH2 , wherein X-NH2 represents a C-terminal .alpha.-amidated amino acid and R represents a remaining portion of the peptide, starting from any step in a series of the following steps: (1) obtaining a fused protein of the formula (0): P-R-X-Gly-B, wherein P represents a partner protein of the fused protein, X represents any amino acid residue, Gly represents a glycine residue, B represents a C-terminal basic amino acid or a basic oligopeptide, and R represents a remaining portion of the peptide, by a gene recombination method; (2) recovering the fused protein; (3) cleaving the fused protein to form a partner protein (P) and a peptide of the formula (I): R-X-Gly-B; (4) separating the peptide (I) from the partner protein (P) on the basis of the difference of the isoelectric points thereof; (5) hydrolyzing the peptide (I) with carboxypeptidase B to form an intermediate peptide of the formula (II) R-X-Gly; and (6) treating the peptide (II) with a C-terminal .alpha.-amidating enzyme. |
| priorityDate | 1989-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 259.