http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2024863-C
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dc7071dfb20088af5bd195d20d112fd4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_92072b5f0b94e632b8326d7a4dc20ecd |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1688 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-32 |
| filingDate | 1990-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2001-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a812c3826cb02fe5dbef6e2c2b863d3c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da20e2a09574ce6f5da425e6b9aec1de |
| publicationDate | 2001-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2024863-C |
| titleOfInvention | The manufacture of pellets of xanthine derivatives |
| abstract | a process for the manufacture of pellets which are composed of xanthine derivatives and are predominantly spherical, have a particle sire in the range from 0.3 to 4 mm and have a bulk density above 0.5 g/cm3 by reacting the appropriate xanthine derivative with water or a water/alcohol mixture, entails anhydrous powdered xanthine derivative with an average particle sire of from 20 to 200 µm being suspended by stirring at from 40 to 70°C in a nonsolvent which is immiscible with water and has a boiling point in the range from 60 to 160°C, then adding from 10 to 40 % by weight, based on the anhydrous xanthine derivative, of water or a water/ alcohol mixture and subsequently allowing to cool to room temperature at from 5 to 20°C per hour, it being possible to reduce the stirring speed after agglomeration to about 1/3 to 2/3 of the original, and the pellets being separa-ted from the liquid and dried, the pellets being used, possibly with a delayed release coating, as active compound in a drug. |
| priorityDate | 1989-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 35.