| abstract |
Pro-drugs of potent 5-lipoxygenase inhibiting compounds comprise compounds of the formula (See formula I) in which A is an alkylene or allcenylene group, X is oxygen, sulfur, sulfoxyl, or substituted nitrogen, and Y is a group which includes substituted or unsubstituted carbocyclic or substituted or unsubstituted heterocyclic aryl. R1 is an alkyl, alkenyl, amino, alkylamino, dialkylamino, or hydroxyamino group or an amine group bearing a metabolically cleavable leaving group. M is hydrogen, a pharmaceutically acceptable cation or a metabolically cleavable leaving group, with the proviso that either M or R1 must bear a metabolically cleavable leaving group. |