| abstract |
A B S T R A C T : MURAMYL DIPEPTIDE DERIVATIVES The 3-0-[N-acetylmuramyl-D-isoglutaminyl]-1,2-di-O-palmitoyl-sn-glycerol derivative of formula I I wherein the carbon atom marked with an asterisk * has the R or, respectively, the S configuration, possesses interesting pharmacological, in particular immunomodulating properties. It is particularly indicated for use as an immunomodulant, as an adjuvant in vaccines and as a suppressing agent for IgE formation in e.g. type I allergies and atopical dermatitises. It is obtained by deprotection of a corresponding compound having one or more hydroxy groups(s) in protected form. |