| titleOfInvention |
Method for preparing 2,3,3a,4,5,6-hexahydro-8-cyclohexyl-1h-pyrazino(3,2,1-j,k) carbazole hydrochloride and antidepressive drug based on this compound |
| abstract |
METHOD FOR PREPARING 2,3,3a,4,5,6-EXAXYDRO-8-CYCLOKEXYL-1H-PYRAZIN0(3,2,1,-j,k)CAR3AZOLE HYDRO-CHLORIDE AND ANTIDEPRESSIVE DRUG BASED ON THIS COMPOUND Abstract A method for preparing 2,3,3a,4,5,6-hexahydro-8--cyclohexyl-1H-pyrazino(3,2,1-j,k)carbazole hydrochloride of the following formula: which involves alkylation of 6-cyclohexyl-3,4-dihydrocar-bazol-1(2H)-one with .beta. -(N,N-dibenzylamino)ethylchlori-de hydrochloride in a two-phase system: an aromatic hydro-carbon 30-40% aqueous solution of an alka1i in the presence of an interphase-transfer catalyst at a temperatu-re of 85-110°C, followed by hydrogenation of the resulting 6-cyclohexyl-9.beta. -(N,N-dibenzylamino)ethyl-3,4-dihydrocar-bazol-1(2H3-one over a palladilIm catalyst supported on a carrier in a lower aliphatic alcohol at a temperature of 50-70°C under a p:ressure of 1 to 30 atm with a subsequent conversion of the resulting 2,3,3a,4,5,6-hexahydro-8-cyclohexyl-1H-pyrazino(3,2,1-jk)-carbazole into hydrochlo-ride and isolation of the latter. The compound according to the present invention exhi-bits an antidepressive activity and is an active principle of a pharmaceutical preparation possessing an antidepres-sant effect. |