http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2018112-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a8659631bf38b3a590c0d3edc265492c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0205 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D281-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0227 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-535 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-08 |
| filingDate | 1990-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba384e142e0cd7a373f0232586e797e2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c53a6f1826df8260dea67287b478a84e |
| publicationDate | 1990-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2018112-A1 |
| titleOfInvention | Compounds |
| abstract | Abstract A compound of formula (I), or a pharmaceutically acceptable salt thereof: (I) wherein either Z1 is absent and Z2, Z3, Z4 and Z5 and the carbon atoms to which Z2 and Z5 are attached, form a 6-membered non-aromatic heterocyclic ring; or Z1, Z2, Z3, Z4, Z5 and the carbon atoms to which Z1 and Z5 are attached, form a 7-membered non-aromatic heterocyclic ring; E is absent or is (CH2)n or CH(CH2)n1- wherein n is 1 to 4; A is -CONH-, -NHCO-, -COO-, -S(O)r- wherein r is 0, 1 or 2, or -CH2-; p is 0, 1 or 2; s is 0, 1, 2, 3 or 4; q is 0 or 1; Rz is hydrogen, C1-6 alkyl or, when A is -CH2-, hydroxy; Ra and Rb are independently selected from hydrogen or a substituent; R1 is CH2R9 wherein R9 is optionally substituted aryl or heteroaryl; R2 is CHR10R11 wherein R10 is hydrogen or methyl and R11 is C1-6 alkyl, C3-8 cycloalkyl, optionally substituted aryl or heteroaryl, or R11 is amino, C2-7 alkanoylamlno, 2-oxopyrrolidinyl, 2-oxopiperidinyl or C1-6 alkoxycarbonylamino; R3 is CH2R12 wherein R12 is C1-6 alkyl, C3-8 cycloalkyl or phenyl; R4 is C1-6 alkyl, C3-8 cycloalkyl, a saturated or unsaturated heterocyclic ring linked through carbon, hydroxy, C1-6 alkoxy, C1-7 alkanoyloxy, amino, C1-7 alkanoylamino, amino substituted by one or two C1-6 alkyl groups, C1-6 alkylsulphonyl, carboxy, C1-6 alkoxycarbonyl, benzyloxycarbonyl, aminocarbonyl or CH(NHR13)CO2R14 wherein R13 is hydrogen or C1-6 alkanoyl and R14 is hydrogen or C1-6 alkyl; or (when s is 2 to 4) R4 is a saturated or unsaturated heterocyclic ring linked through nitrogen; and the dashed line represents an optional bond (when E is present); which are renin inhibitors. |
| priorityDate | 1989-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 225.