http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2017741-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cef5045e7639c28010832b4eae012eb1 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F15-0093 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-282 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-28 |
| filingDate | 1990-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12ed64ba7b7504a61beb2035bf82719c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dde5acbd01ca69d3e599bd1973e615f6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e7ca4939430f4aa1fa93a85b2bb3f7e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a85e6bc4beb1ac9c52a904991afc7596 |
| publicationDate | 1991-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2017741-A1 |
| titleOfInvention | Platinum triamine antitumor agents containing substituted anilines |
| abstract | ABSTRACT OF THE DISCLOSURE Platinum (II) antitumor agents of the general formula: Y wherein A1 and A2 are the same or different and are selected from ammonia or a monodentate amine and substituted monodentate amines, or A1 and A2 together are a diamine represented by the general formula: wherein R2 and R3 are the same or different and are each selected from hydrogen, linear or branched C1-C6 alkyl and substituted linear or branched C1-C6 alkyl wherein the substituents are selected from hydroxy, C1-C4 alkoxy, halo, carboxy, C1-C4 alkylcarboxy or C1-C4 alkoxylcarbonyl, or R2 and R3, taken together, form a 1,2-diaminocycloalkane containing 4-8 nuclear carbon atoms or a substituted 1,2-diaminocycloalkane wherein the substituents are selected from linear or branched C1-C6 alkyl groups, hydroxy, C1-C4 alkoxy, halo, carboxy, C1-C4 alkylcarboxy or C1-C4 alkoxylcarbonyl; wherein L is aniline or aniline substituted with one or more of C1-C6 linear or branched alkyl, hydroxy, C1-C4 alkoxy, halo, carboxy, cyano, isocyano, phenyl, nitro, C1-C4 alkylcarboxy or C1-C4 alkoxylcarbonyl; wherein X is a monodentate anionic ligand and wherein Y is an anion. Members of this class of compounds have demonstrated activity in a number of in vivo antitumor screens. The platinum-triamine complexes are typically cationic species and as such possess desirable physical properties which include high stability and solubility in aqueous media. |
| priorityDate | 1989-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 63.