http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2015072-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a09fa84c54c24536575f7f12c1f1db43 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H17-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H17-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7042 |
| filingDate | 1990-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_36de97aa6cbc0974623fd2ef0a5dcf10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac3c84f72af24f79a316c6651b961b53 |
| publicationDate | 1990-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2015072-A1 |
| titleOfInvention | Process for the preparation of glucosaminyl-epi-podophyllotoxin derivatives |
| abstract | Abstract of the disclosure: HOE 89/B 015 A process for the preparation of glucosaminyl-epi-podo-phyllotoxin derivatives The invention relates to a novel process for the prepara-tion of glucosaminyl-epi-podophyllotoxin derivatives of the formula I I in which R1 is hydrogen or the acetyl or a mono-, di- or trihalo-genoacetyl protective group with halogen being fluor-ine, chlorine or bromine, R2 is hydrogen or (C1-C4)-alkyl, R3 hydrogen, (C1-C4)-alkyl or a benzyloxycarbonyl protective group, R4 is hydrogen, a mono-, di or trihalogenoacetyl pro-tective group, a benzyloxycarbonyl protective group or a methyl group, and A is C1-C4-alkyl, which comprises reacting a 3-0-acyl-2-N-benzyloxy-carbonyl-4,6-0-alkylidene-alpha-D-glucosamine derivative of the formula II, which is in the alpha-hydroxy form, II in which R1 and R3 are acyl protective groups as defined above, and R2 is hydrogen, with a podophyllotoxin derivative of the formula III III in which R4 is a methyl group or a mono-, di- or trihalogenoacetyl or benzyloxycarbonyl protective group, in the presence of a promoter and of an anhydrous organic solvent at -50°C to 20°C to give a 4-O-(beta-glucosamin-yl)-epi-podophyllotoxin derivative of the formula I in which the radicals R1, R2, R3, and R4 retain their meaning as defined above, and subsequently converting the glyco-side products of the formula I, after elimination of the protective groups, into an amino or dialkylamino compound of the formula I. |
| priorityDate | 1989-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 94.