| abstract |
1/11/89:Fl TITLE OF THE INVENTION MICROBIAL TRANSFORMATION PRODUCT OF L-679,934 ABSTRACT OF THE DISCLOSURE Described is a new immunosuppressant, L-683,519, a monodemethylated rearranged derivative of L-679,934, produced under fermentation conditions utilizing the microorganism, unidentified Actinomycete (Merck Culture Collection MA 6474) ATCC No. 53828. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants. |