| abstract |
Certain N-(substituted)-1-heteroaryl-oxindole-3-carboxamides wharein the N-substituent is thienyl, furyl, phenyl or substituted phenyl, are inhibitors of cycloxygenase and lipoxygenase enzymes and are useful as anti-inflammatory agents in mammals, (see fig.I) (I) (wherein R1 is thienyl, furyl or 2-thiazolyl; R is thienyl, furyl or [in which X is H, F, Cl, C1-4alkyl, C1-4alkoxy, C1-4alkylthio, nitro or CF3; and Y is H, F or Cl]; and R3 and R4 may be the same or different and are H, F, Cl, Br, C1-4alkyl, C1-4alkoxy, C1-4alkylthio nitro of CF3). |