| abstract |
The dermal use of non-irritating retinoids such as the esters and amides of 13-cis and 13-trans-retinoic acid for effecting the reduction and reversal of photoaging and skin cancer is disclosed. The retinoids having the formulae: wherein R is , , , , , , , , , , , , , , and wherein X is -H, -F, -Cl, -Br, -I, -OH, -OR, -OR', , , , -CN, -NO2, -NH2, -NHR', or -NR'2; wherein n is a number from 1 to 5; wherein R' is H or any of the lower alkyls ranging from C1 to C6; wherein R" is , -OR', , or -R'; wherein each R~ is R' or the hydrocarbon backbone of fatty acids; and further, where there are two or more R', R", or R~ groups attached to the same carbon or nitrogen, each R', R", or R~ may be the same as or different from the other R', R", or R~ groups attached to that carbon or nitrogen, |