http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2001094-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_83948bcd02df1435901159728b66fee2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_15da4f045a7702a97a67c3418b42f921 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7baa7d7295309bb55b9720e33752ef7c |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-57527 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-575 |
| filingDate | 1989-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e8206aac207ab9f1d9f80eaeec2d626 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ada1f7c5e239daea50fe7c72437c5935 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f8dfefc5462f241125395e181dc0d2e |
| publicationDate | 1990-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2001094-A1 |
| titleOfInvention | Chemical compounds |
| abstract | A B S T R A C T Novel analogues of calcitonin gene related peptide comprise analogues of natural CGRPs modified at at least two of positions 3, 22 and 25. These compounds are of general formula NH2-Ala-Cys-A-aa.alpha.-B-C-Lys-D-aa.beta.-CONH2 wherein A is a carboxylate or amide substituted amino acid or amino acid analogue; aa.alpha. is substantially the amino acid sequence of a CGRP from position 4 to position 21; B is a hydrocarbyl or thio substituted amino acid or amino acid analogue; C is valine or glycine; D is an amine or hydroxyl substituted amino acid or amino acid analogue. The novel analogues may comprise natural amino acid residues. Preferably A is aspartate or asparagine, B is valine or methionine, C is valine and D is asparagine or serine. The analogues exhibit desirable cardiovascular properties and are potentially useful in therapy, e.g. for treatment of deficiencies in cerebral blood supply. |
| priorityDate | 1988-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 124.