http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-1341374-C
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cb8f3eba86915d967beefc175437273a |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
filingDate | 1987-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2002-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f65b645824af7676b98a520792e0a818 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_581e2130bbb9ac5f09e82326737e94f0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31a6467f7a72ef623036e1f0a2cd9ee5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc219a9a5ce0d3e6cafcda521bfc23b2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14c571a94f4fd574e15bc9ce4046cb9b |
publicationDate | 2002-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CA-1341374-C |
titleOfInvention | Compositions and method for treatment of cancer using monoclonal antibody against gd3 ganglioside together with il-2 |
abstract | Cell surface gangliosides are presumed to play a role in cell growth and differentiation. Using monoclonal antibodies directed against G D3, a disialoganglioside expressed predominantly by cells of neuroectodermal origin, we have found that G D3 is expressed by a subpopulation of cells of the immune system including: a) fetal thymocytes in subcortical regions and near vessels, 2) lymph node lymphocytes in interfollicular areas and near vessels, and 3) a small subset of T cells in the peripheral blood. Mouse monoclonal antibodies (two IgGs, one IgM and F(ab')2 fragments) reacting with G D3 were found to stimulate proliferation of T cells derived from peripheral blood. Proliferation induced by binding to G D3 could be augmented by exogenous IL-2, PMA, PHA or Protein A. |
priorityDate | 1986-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 415.