| abstract |
New substituted pyridines can be prepared by reduction of pyridines which are substituted by a ketone radical, and subsequent hydrolysis, cyclization or hydrogenation. The new compounds can be used as active compounds in medicaments, particularly for inhibiting HMG-CoA reductase, for inhibiting cholesterol biosynthesis or for the treatment of hyperlipoproteinaemia, lipoproteinaemia or arteriosclerosis. |