| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cd9f27818dd76ad09545b7075f612830
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_df63d25169d82fc1d6724b76c3e46f96
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c5fc8123112553cd26ecc39e4de0ddb7 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-565
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-1133 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-565 |
| filingDate |
1988-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1999-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b24135f530ccca3ae13ed4d3990000d7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd1c562b33745bc4c483a59be3895f2d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8089fa6ff05349c2a429507752b8c4f3 |
| publicationDate |
1999-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-1340586-C |
| titleOfInvention |
Process for recovering microbially produced interferon-beta |
| abstract |
An approved procedure for the purification and renaturation of biologically active, bacterially produced IFN-beta is described. The partially purified material obtained by solubilization of isolated refractile bodies from the recombinant cells is treated to obtain reduction of the protein in the presence of a chaotropic environment and then oxidized after removal of the reducing agent. However, the chaotropic environment is retained during the oxidation. Upon removal of the chaotropic environment, a solubilizing additive is supplied to maintain the IFN-beta in solution. Further purification by conventional means may also be effected. |
| priorityDate |
1988-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |