| abstract |
There are described cephem compounds of the formula: wherein R1 is amino or a protected amino, R is lower alkyl which may have one or more suitable substituent (s), R3 is COO?, carboxy or a protected carboxy , R4 is hydroxy (lower) alkyl or protected hydroxy (lower) alkyl, R5 is amino or a protected amino, R6 is hydrogen or lower alkyl, X? is an anion, and n is 0 or 1, with proviso that (i) when R3 is COO?, then n is 0, and (ii) when R3 is carboxy or a protected carboxy, then n is 1, and pharmaceutically acceptable salt thereof. The process of producing same as well as pharma-ceutical compositions containing hte cephem compounds are also described. These compounds are highly active against a number of pathogenic microorganisms. |