abstract |
Cephalosporin and 1-carba(1-dethia)ceph-alosporin antibiotics substituted in the 3-position with, inter alia, alkyl, alkenyl and alkynyl, are provided via a process comprising conversion of a cephalosporin or 1-carba(1-dethia)-3-cephem sub-stituted in the 3-position with halogen or a sulfonyloxy ester with Pd(O) mediated alkylation with organostannanes. |