| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d313dce6b318f9cc1ab4dcebd2003fdf |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-575
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-10 |
| filingDate |
1987-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1996-01-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f7688e813e37410b7b52af38d4e2692f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae1e0b92a711f80b091461b745fcd6f8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_efba98ef0056de0e5aade45b73033430 |
| publicationDate |
1996-01-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-1337891-C |
| titleOfInvention |
Anf derivatives with novel bridging |
| abstract |
Disclosed herein are derivatives of atrial natriuretic peptides wherein the exocyclic N-terminal peptide segment is deleted and the two cysteinyl residues (at positions 105 and 121) of the natural sequence are replaced with a trivalent unit, -NHCH(CO-)-Q-X-Y-CH2CH2CO- wherein Q is methyl-ene, ethylene or CR'R" wherein R' and R" each in-dependently is lower alkyl, X is oxy or thio, and Y is methylene or des-Y. The derivatives may be optionally substituted at various positions includ-ing positions 106, 107 and 124. The derivatives possess protracted ANF-like activity and are indi-cated for treating hypertension and for treating pathological conditions resulting from an imbalance of body fluids and electrolytes. |
| priorityDate |
1987-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |