http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-1336714-C
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2baf849d216e689ecc40ccc931a7a7bc |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 |
| filingDate | 1988-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1995-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9984742e8bff1b26187abafb96ea5081 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d7bc9de719487c15ffa5924697dbcc39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5877442c97f966099662694dab5f30e0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5935accf2eeab22ee7a8ba2121dc539b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a25d3e61061fbaa9b82004603ae4dbee |
| publicationDate | 1995-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-1336714-C |
| titleOfInvention | Quinoline type mevalonolactone inhibitors of cholesterol biosynthesis |
| abstract | A compound of the formula: (I) wherein R1, R2, R3, R4 and R6 are independently hydrogen, C1-6 alkyl, C1-6cycloalkyl, C1-3 alkoxy, n-botoxy, i-botoxy, sec-butoxy, R7R8N- (wherein R7 and R8 are independently hydrogen or C1-3 alkyl), trifluoromethyl, trifluoromethoxy, difluoromethoxy, fluoro, chloro, bromo, phenyl, phenoxy, benzyloxy, hydroxy, trimethylsilyloxy, diphenyl-t-butylsilyloxy, hydroxymethyl or -O(CH2)?OR19 (wherein R19 is hydrogen or C1-3 alkyl, and ? is 1,2 or 3); or when located at the ortho position to each other, R1 and R2, or R3 and R4 together form -CH=CH-CH=CH-; or when located at the ortho position to each other, R1 and R2 together form -OC(R15)(R16)O-(wherein R15 and R16 are independently hydrogen or C1-3 alkyl); Y is -CH2-, -CH2CH2-, -CH=CH-, -CH2-CH=CH- or -CH=CH-CH2-; and Z is -Q-CH2WCH2-CO2R12, or (wherein Q is -C(O)-, -C(OR13)2- or -CH(OH)-; W is -C(O)-, -C(OR13)2- or -C(R11)(OH)-; R11 is hydrogen atom or C1-3 alkyl; R12 is hydrogen or R14 (wherein R14 is physiologically hydrolyzable alkyl or M (wherein M is NH4, sodium, potassium, 1/2 calcium or a hydrate of lower alkyl amine, di-lower alkyl amine or tri-lower alkyl amine)); two R13 are independently primary or secondary C1-6 alkyl; or two R13 together form -(CH2)2- or -(CH2)3; R17 and R18 are independently hydrogen or C1-3 alkyl; and R5 is hydrogen, C1-6 alkyl, C2-3 alkenyl, C3-6 cycloalkyl, (wherein R9 is a hydrogen atom, C1-4 alkyl, C1-3 alkoxy, fluoro, chloro, bromo or trifluoromethyl), phenyl-(CH2)m- (wherein m is 1,2 or 3), -(CH2)nCH(CH3)-phenyl or phenyl-(CH2)nCH(CH3)- (wherein n is 0,1 or 2). |
| priorityDate | 1987-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 118.