abstract |
Disclosed are substituted tetralins, chromans and related compounds of the formula: ---(I) (wherein n is 0 or 1; m is 0, 1, 2 or 3; X is CH2, O, S, SO, SO2, NH or N(C1-C4)alkyl; X1 is CH2, O, S, SO or SO2; Y and Y1 together form CO or Y is H and Y1 is OH or acyloxy; Z is lower alkylene; Z1 is CH or N; R1 is an optionally substituted N-containing heterocyclic ring such as pyridyl, quinolyl, isoquinolyl, pyridazinyl, cinnolyl, phthalazinyl, pyrimidinyl, quinazolyl, pyrazinyl, quinoxalinyl etc.; and R1 is an optionally substituted aromatic carbocyclic or heterocyclic ring such as phenyl, naphthyl, pyridyl, quinolyl, isoquinolyl, pyridazinyl, cinnolinyl) which, by inhibiting 5-lipoxygenase enzyme and/or blocking leukotriene receptors, are useful in the prevention or treatment of asthma, arthritis, psoriasis, ulcers, myocardial infarction and related disease states in mammals; pharmaceutical compositions thereof; and intermediates useful in the synthesis thereof. |