http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-1327037-C
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a1ca2fe5a1e9022aa0323cbb48d30f5e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-40 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 |
| filingDate | 1989-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1994-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3013f33547091c50cb112f790cd327a0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a7eac9cfaf82f401466cd2a607f02f9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_68bfdc846de7561ca55c6de996ca9ebc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41897400084d56d4c1f3e28e14dd613b |
| publicationDate | 1994-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-1327037-C |
| titleOfInvention | Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof |
| abstract | ABSTRACT The invention relates to certain derivatives of mitomycins A and C having good anti-neo-plastic properties and low bone marrow and overall toxicity comprising: wherein, n is 0 or 1; Y is selected from the group consisting of glucopyranosyl, galactopyranosyl, mannopyranosyl, xylopyranosyl, cellobiosyl, lactosyl, glucofuranosyl, maltosyl, and 1,3-cyclohexanediol-2-yl or the hydroxyl-protected acetate derivatives thereof; R is hydrogen; R1 is hydrogen, C1-C4 alkyl or C1-C4 allyl substituted by phenyl, hydroxyphenyl,indolyl, mercapto, C1-C4 allylthio, hydroxy, carboxy, amino, guanidino, inidazole or carbamyl; or R and R1 form a five or six membered ring containing nitrogen; or wherein, n, Y, R and R1 are the same as above; and R2 is NH2 or CH3O-; or wherein, R2 is as defined above; and R3 is a 3-cyano-4-morpholinyl-2-deoxypyranosyl saccharide or a 4-morpholinyl-2-deoxypyranosyl saccharide; and to methods for the preparation and use of the mitomycin derivatives. |
| priorityDate | 1988-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 173.