http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-1324150-C
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_589e019870e8f74165d0734073a38d8e |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-28 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F15-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F13-00 |
filingDate | 1987-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 1993-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e7a5143877b878ccb04bffefe6f3749 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a1b3142615d7fb492c20fb1ad97b30a4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_98ea15e452b26cad9251bfc503b3988d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_15b23bcfe49b7966c7d59bfcd4a51068 |
publicationDate | 1993-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CA-1324150-C |
titleOfInvention | Paramagnetic chelates useful for nmr imaging |
abstract | - a -ABSTRACT OF THE DISCLOSURE Compounds suitable for NMR imaging having the formula: (I) wherein a is 2 or 3; b is an integer from 0 to 4; Me(a+) is Fe(2+), F2(3+), Gd(3+) or Mn(2+); E(b+) is an ion of an alkali metal, alkaline earth metal, alkyl ammonium, alkanol ammonium, polyhydroxyalkyl ammonium, or basic protonated amino acid, said ions representing a total charge of b; m is an integer from 1 to 5; R is H, alkyl with from 1 to 8 carbon atoms, alkyl with from 1 to 8 carbon atoms wherein from 1 to 5 carbons are substituted with OH; aralkyl with 1 to 4 aliphatic carbon atoms; phenyl or phenyl substituted by halogen, hydroxyl, carboxyl, carboxamide, ester, SO3H, sulfonamide, lower alkyl, lower hydroxy alkyl, amino, acylamino; (poly)oxa-alkyl with 1 to 50 oxygen atoms and from 3 to 150 carbon atoms, wherein 1 to 5 hydrogen atoms may be substituted by OH; - b -R1 is the same as R2 or is -CH2COOZ, -CH(CH3)COOZ, CH2CH2-N(CH2COOZ)2, a hydroxy arylalkyl, hydroxy pyridylalkyl, hydroxy aryl(carboxy)alkyl or hydroxy pyridyl-(carboxy)-alkyl radical, where the aryl or pyridyl radical may be substituted by hydroxyl, hydroxy alkyl, alkyl, halogen, carboxyl or SO3H; R2 is -CH2COOZ, -CH(CH3)COOZ, , , or ; wherein R3 is -CH2COOZ, -CH(CH3)COOZ or a monovalent radical having the structure R-O-(CH2)m-?H-COOZ; X is a direct chemical bond, -O-, -S-, -NH-, -?-CH2COOZ or -?-CH(CH3)COOZ; n is the integer 2 or 3, with the proviso that when X represents a direct bond, n is 1, 2 or 3; Z is hydrogen or a unit of negative charge, and -(CH2)m- may also be -CH2-C(CH3)2-. The compounds are relatively simple, well tolerated, partially endowed with organ specificity and are suitable for application in nuclear spin tomography. The compounds may be - c -prepared by reacting inventive free polyamino-polycarboxylic acids having the formula (Ia) where R, R1, R2 and m have the same meaning as in formula I, or alkali metal, alkaline earth metal and/or amino salts of said acids, with salts, oxides, or hydroxides of iron(2+), iron(3+), gadolinium(3+), or manganese(2+), or with the basic salts of these metal ions. Imaging compositions and methods of use are also disclosed. |
priorityDate | 1986-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 148.